Abstract
A pexiganan–chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.
ACKNOWLEDGMENTS
Thanks are due to FCT (Portugal) for financial support to LAQUIPAI (C. G.) and to CIQUP (P. G.) and also for PhD grant SFRH/BD/13144/2003 (M. B.).
Notes
a Cys was not considered, as its quantitation by AAA is not reliable.
b In injected sample, after known dilutions of the original hydrolysate.
c From the pexiganan-Ala-Ala-Cys amino acid sequence.