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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 9
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Original Articles

Synthesis of Novel Pyrrolo-[3,2-c]quinolines via Iron-Catalyzed Cross-Coupling Reaction of Grignard Reagents

, , , &
Pages 1583-1591 | Received 11 Sep 2008, Published online: 02 Apr 2009
 

Abstract

Cross-coupling reaction of alkyl and aryl magnesium halides with 4-chloro-pyrrolo-[3,2-c]quinoline in the presence of a catalytic amount of iron salt is described. The reactions are completed in 30 min, resulting in moderate to excellent yields of 52–94% in a tetrahydrofuran (THF)–N-methylpyrrolidinone (NMP) solvent mixture.

ACKNOWLEDGMENT

We thank the Ministère de l'Education Nationale, de la Recherche et de la Technologie (MENRT), the Centre National de la Recherche Scientifique (CNRS), and la Ligue contre le Cancer for financial support.

Notes

a Isolated yield after purification on column chromatography;

b The product was recovered by crystallization from CH2Cl2.

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