Iodine-Catalyzed Synthesis of 12-Aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one Derivatives via Multicomponent Reaction

Abstract

Iodine efficiently catalyzes the one-pot, three-component reaction of aryl aldehyde, 2-naphthol, and cyclic 1,3-dicarbonyl compound under solvent-free conventional heating conditions to afford the corresponding 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one derivatives. The present approach offers several advantages such as shorter reaction times, good yields, low cost, and mild reaction conditions.

Keywords:

• Aldehyde
• iodine
• multicomponent reaction
• β-naphthol
• solvent-free conditions
• xanthene

ACKNOWLEDGMENTS

We are grateful for financial support from Hebei Normal University (L2008Y05) and the Nature Science Foundation of Hebei Province (B2008000149).

Notes

^a Isolated yield.