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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 12
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Original Articles

Simple System for Cleavage of Alkene C–C Bond Using Aqueous Sodium Paraperiodate

, &
Pages 2146-2150 | Received 16 Oct 2008, Published online: 12 May 2009
 

Abstract

A simple and mild method for direct conversion of alkenes to corresponding aldehydes has been developed using sodium paraperiodate (Na3H2IO6) in water. The reagent was found to give excellent yields of corresponding aldehydes.

ACKNOWLEDGMENT

We gratefully acknowledge the University Grants Commission, India, for financial support under the scheme of a UGC major research project.

Notes

a Typically, Na3H2IO6 (12 mmol) reacted with substrate (10 mmol) in water (25 mL) at 70°C.

b Starting compounds were prepared by standard literature procedures.

c Isolated yields after column chromatography and structure was confirmed by comparison of IR and 1H NMR with those of authentic materials.

d NR: no reaction.

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