Iodobenzene Diacetate Mediated Oxidation of N-Substituted Hydrazones of Chalcones: An Efficient Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles

Abstract

Iodobenzene diacetate, a relatively benign nonmetallic oxidant, has been utilized efficiently for the oxidation of N-substituted hydrazones of chalcones to afford 1,3,5-trisubstituted pyrazoles under mild reaction conditions.

Keywords:

• Iodobenzene diacetate
• oxidative cyclization
• regioselective
• N-substituted hydrazones of chalcones
• 1,3,5-trisubstituted pyrazoles

ACKNOWLEDGMENTS

We thank the Council of Scientific and Industrial Research, New Delhi, for financial assistance and a junior research fellowship to Rajiv Kumar. Thanks are also due to Regional Sophisticated Analytical Instrumentation Facility, Central Drug Research Institute, Lucknow, India, for providing ¹⁹F NMR spectra, mass spectrometry, and elemental analysis. We also thank Professor S. P. Singh for helpful suggestions.