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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 12
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Original Articles

Convenient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using TMSCl as a Catalyst with Ultrasonic Irradiation in DMF

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Pages 2205-2220 | Received 17 Jul 2008, Published online: 13 May 2009
 

Abstract

3,4-Dihydropyrimidin-2(1H)-one and their derivatives were synthesized in good yields (90–99%) by a one-pot, three-component Biginelli cyclocondensation of dimedone, aldehydes, and urea in the presence of trimethylsilyl chloride (TMSCl) in dimethylformamide (DMF).

ACKNOWLEDGMENTS

This work was funded by the Natural Science Foundation of Zhejiang Province, China (Project Y407240).

Notes

a All reactions were performed using 4-phenylsulfanyl-benzaldehyde (2 mmol), urea (2 mmol), dimedone (2 mmol), and TMSCl (8 mmol).

b Isolated yields.

a All reactions were performed using aldehyde (2 mmol), urea (2 mmol), dimedone (2 mmol), and TMSCl (8 mmol).

b All the products were characterized by 1H NMR, IR, and mass spectral data.

c Isolated yields.

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