General and Green Synthesis of C-6 Sulfonylmethyl 4-Aryl-3,4-dihydropyrimidinones in Water

Zheng-Jun Quan Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China

Qiang-Bing Wei Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China

Dong-Dong Ma Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China

Yu-Xia Da Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China

Xi-Cun Wang Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, ChinaCorrespondence[email protected]

Mao-Sen Shen Jing Tai Second Middle School, Baiyin, Gansu, China

Abstract

A simple, inexpensive, and green reaction permitting the synthesis of new C-6 arylsulfonylmethyl 4-aryl-3,4-dihydropyrimidinones in water by S-alkylation of 6-bromomethyl 3,4-dihydropyrimidinones 2 with benzenesulfinic acid anions 3 is reported. The required 6-bromomethyldihydropyrimidone precursors 2 were readily prepared using an organic solid brominating reagent.

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ACKNOWLEDGMENT

We are thankful for the financial support from the Natural Science Foundation of Gansu Province (3ZS061-A25-019) and the Scientific Research Fund of Gansu Provincial Education Department (0601-25).

Notes

^aReaction conditions: a mixture of 1 equiv. of 2a with 2 equiv. of 3a was heated under reflux condtions for 24 h.

^bIsolated yield.

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General and Green Synthesis of C-6 Sulfonylmethyl 4-Aryl-3,4-dihydropyrimidinones in Water

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General and Green Synthesis of C-6 Sulfonylmethyl 4-Aryl-3,4-dihydropyrimidinones in Water

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ACKNOWLEDGMENT

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