Dually Activated Organo- and Nano-cocatalyzed Synthesis of Coumarin Derivatives

Abstract

A wide range of substituted coumarin derivatives were synthesized by refluxing in acetonitrile, ethyl acetoacetate, and ethyl benzoyl acetate with a wide range of structurally diverse phenol derivatives within a short reaction time with a catalytic combination of pyridine dicarboxylic acid as organocatalyst and nanocrystalline ZnO.

Keywords:

• Co-catalyst
• coumarins
• dual activation
• Pechmann reaction
• phenols

ACKNOWLEDGMENTS

The work was carried out with Financial Grant No. SR/FTP/CS-15/2007 of the Department of Science and Technology, New Delhi, India. The director, Indian Institute of Technology, Guwahati, is given special thanks for access to the research facility to carry out this work.

Notes

^a Yields refer to isolated yield.

^b All the compounds were characterized by NMR, mass, and elemental analyses.

^a Yields refer to isolated yield.

^b All the compounds were characterized by NMR, mass, and elemental analyses.