Copper Acetate–Catalyzed, Mild, Highly Efficient, and Practical Synthesis of Thiazoles and Aminothiazoles

Abstract

A mild and highly efficient synthesis of thiazoles by the condensation of α-bromo ketones with thiourea in the presence of a catalytic amount of copper acetate at room temperature has been described. The method is applicable for a variety of aryl and alkyl α-bromo ketones. The catalyst is inexpensive, and substituted thiazoles are obtained in good yields.

Keywords:

• α-Bromo ketones
• condensation
• copper(II) acetate
• thiazoles

ACKNOWLEDGMENTS

D. A. and B. R. V. P. thank the Counsil of Scientific and Industrial Research for the award of a fellowship and J. S. Yadav, director, Indian Institute of Chemical Technology, for his support and encouragement.

Notes

^a All the products were characterized by ¹H NMR, IR, and mass spectroscopy.

^b Isolated yields after purification.