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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 13
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Original Articles

Novel and Efficient Route for the Synthesis of 4-Aryl-Substituted 2(5H)-Furanones

, , , , , & show all
Pages 2423-2429 | Received 22 Aug 2008, Published online: 01 Jun 2009
 

Abstract

4-Aryl-substituted 2(5H)-furanones were prepared by reaction of diethylphosphono acetic acid and phenacyl bromides, followed by an intramolecular Horner–Emmons-type cyclization. Both the reactions were carried out in situ to give the desired 4-aryl substituted 2(5H)-furanone derivatives.

ACKNOWLEDGMENT

The authors are thankful to the management of Cadila Healthcare Limited for the support of this research.

Notes

ZRC Communication No. 228.

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