Abstract
A series of furo[2′,1′:5,6]pyrido[2,3-d]pyrimidine derivatives were synthesized via the three-component reaction of an aldehyde, tetronic acid, and 6-amino-1,3-dimethyl-pyrimidine-2,4-dione in aqueous media without the use of catalyst. This protocol has the advantages of better yields, less cost, reduced environmental impact, and convenient procedure.
ACKNOWLEDGMENT
We are grateful to the Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province for financial support.