Abstract
Solvent-free acetylation of alcohols, phenols, amines, and thiols with acetic anhydride (Ac2O) in the presence of 0.1 mol% (13 mg) anhydrous NiCl2, an inexpensive and easily available catalyst. Excellent yields, short reaction time, and mild reaction conditions are important features of this method.
ACKNOWLEDGMENT
The authors acknowledge the partial support of this work by Prof. B. P. Bandgar, Vice chancellor, University of Solapur, India.
Notes
a Isolated yield of the corresponding acetylated product.
a The substrate was treated with 1 equiv. of the anhydride in the presence of 0.1 mol% (13 mg) of catalyst under solvent-free conditions at room temperature.
b Isolated yield of the corresponding acetylated product.
a Yields refer to pure products. All products were characterized by comparison of their IR spectra, 1H NMR spectra, and elemental analysis with those of authentic samples.