Knoevenagel Condensation of Aldehydes with Meldrum's Acid in Ionic Liquids

Abstract

The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF₄ at room temperature in the presence of catalytic amounts of piperidine.

Keywords:

• Active methylene compounds
• ionic liquid
• Knoevenagel condensation
• Meldrum's acid

ACKNOWLEDGMENT

This work was supported by an Indiana University–Purdue University Fort Wayne Summer Faculty Research Grant.

Notes

^a All reactions run with 4-methoxybenzaldehyde (2 mmol) and Meldrum's acid (2 mmol) in ionic liquids (1 g) at room temperature for 10 h.

^b Isolated 3e yields.

^a At room temperature in [bmim]BF₄ in the presence of 10 µL piperidine as the catalyst.

^b Isolated yields.