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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 14
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Original Articles

Aminolysis of 3-Phenyl Propylthiol Esters Leading to Diverse Sets of Amides

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Pages 2614-2624 | Received 28 Jul 2008, Published online: 16 Jun 2009
 

Abstract

3-Phenyl propylthiol esters were investigated as “activatable” solution phase linkers. These linkers can be activated with silver salts and upon treatment with amines can be converted to the corresponding amides. Under unactivated conditions, the linker is stable to a variety of reagents and reaction conditions including treatment with amines.

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