Abstract
5-Chloro-7-[1,3]oxazolo[4,5-b]pyridin-2-ylquinolin-8-ol was synthesized by a Pd-catalyzed arylation, which proceeds efficiently with 2 equivalents of benzylated clioquinol and 1 equivalent of oxazolo[4,5-b]pyridine. The product was smoothly debenzylated by boron trichloride in dichloromethane.
ACKNOWLEDGMENTS
We thank the European Union for a Marie Curie fellowship (MIF1-CT-2005-514549), PERCH-CIC, Faculty of Science, Mahasarakham University, for the research fellowship, and Leeds University for support.
Notes
a Conditions: 2 (2 mol equiv), 3 (1 mol equiv), 5 mol% Pd, 20 mol% ligand, and Cs2CO3 (2 mol equiv).
b Isolated yield.
c Reaction run at room temperature; no product was detected.
d 10 mol% Pd, 40 mol% PPh3.
e 10 mol% Pd, 20 mol% PPh3.