Green Method for the Synthesis of Benzo[f]pyrimido[4,5-b]quinoline Derivatives Catalyzed by Iodine in Aqueous Media

Abstract

A convenient one-pot synthesis of benzo[f]pyrimido[4,5-b]quinoline derivatives is described via three-component reaction of benzaldehydes, naphthalen-2-amine, and barbituric acid at room temperature in aqueous media catalyzed by iodine. Compared with other methods, this three-component reaction used a green solvent, gave good yields, and was operationally simple.

Keywords:

• Aqueous media
• benzo[f]pyrimido[4,5-b]quinoline
• iodine
• three-component reaction

ACKNOWLEDGMENTS

We are grateful to the National Natural Science Foundation of China (20802061), the Natural Science Foundation (08KJD150019), and Qing Lan Project (08QLT001) of Jiangsu Education Committee for financial support.

Notes

^a Reagents and conditions: 1 (2 mmol), 2 (2 mmol), 3 (2 mmol), and solvent (10 mL).

^b Isolated yields.