Efficient Approach to the Synthesis of Ethyl 3-Amino-4,6-diarylfuro[2,3-b]pyridine-2-carboxylate

Abstract

Novel ethyl 3-amino-4,6-diarylfuro[2,3-b]pyridine-2-carboxylate were synthesized by Thorpe–Ziegler cyclization using solid–liquid phase-transfer catalysis conditions.

Keywords:

• Furo[2,3-b]pyridine
• heterocyclization
• solid–liquid PTC
• Thorpe–Zeigler reaction

ACKNOWLEDGMENTS

We thank the Regional Sophisticated Instrumentation Center, Central Drug Research Institute, Lucknow and Chandigarh, India, for ¹H NMR and mass spectral analysis and Dishman Pharmaceuticals and Chemicals Ltd. for their support.

Notes

^a Isolated yields.

^a Isolated yields.

Dedicated to the memory of Dr. Chaitanya G. Dave.