Design and Synthesis of Novel 5-Acetylthiomethyl Oxazolidinone Analogs

Abstract

The oxazolidinone class of antimicrobial agents represents a promising advance in the fight against resistant Gram-positive bacterial infections. To improve antibacterial activity and expand the spectrum of activity including Gram-negative bacteria, a series of novel 5-acetylthiomethyl oxazolidinone analogs were designed and synthesized based on the structure–activity relationship studies. The structures of the target compounds and main intermediates were confirmed by ¹H NMR, ¹³C NMR, infrared (IR), mass spectra (MS), and elemental analysis.

Keywords:

• Antibacterial agent
• drug-resistant
• oxazolidinone
• synthesis

ACKNOWLEDGMENTS

We are grateful for the financial support of the National Natural Science Foundation of China (No. 30672537) and Chengdu Entry Scientific and Technological Development Co., Ltd.