Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide

Abstract

Efficient enantioselective synthesis of (R)- and (S)-enantiomers of 2-(tert-butylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol.

Keywords:

• β-Amino-arylethanols
• asymmetric sulfoxide
• bronchodilator
• chiral auxiliary
• salbutamol

ACKNOWLEDGMENT

We thank the Department of Science and Technology, New Delhi, for financial support.