Efficient and Facile Synthesis of 3-Amino-1-aryl-9H-fluorene-2,4-dicarbonitrile Under Solvent-Free Conditions

Abstract

A versatile and efficient route to 3-amino-1-aryl-9H-fluorene-2,4-dicarbonitrile via multicomponent reactions of 1-indanone, aromatic aldehydes, and malononitrile under solvent-free conditions using NaOH as the catalyst is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature and direct isolation of the products in good yields.

Keywords:

• Fluorene
• grinding
• multicomponent reactions
• solvent-free
• synthesis

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the PeiYu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.