Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2009 - Issue 2
536
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of 4-Substituted Styrene Compounds via Palladium-Catalyzed Suzuki Coupling Reaction Using Free Phosphine Ligand in Air

&
Pages 196-205 | Received 31 Oct 2008, Published online: 29 Dec 2009
 

Abstract

The air-stable and easy to prepare nonsymmetric Schiff base ligands have been synthesized and proven to be efficient ligands for Suzuki cross-coupling reaction between aryl bromides and arylboronic acids using PdCl2(CH3CN)2 as palladium source under aerobic conditions. The coupling reaction proceeded smoothly using N-[(3,4-dimethoxyphenyl)methylene]-1,2-benzenediamine (L3) as ligand under mild conditions to provide 4-substituted styrene compounds in good yields.

Notes

a Reaction conditions: p-bromostyrene (0.50 mmol), phenylboronic acids (0.75 mmol), PdCl2(CH3CN)2 (0.5% mmol), base (1.5 mmol), solution (2.0 mL), temperature 80°C, reaction time 10 h.

b Isolated yield.

a Reaction conditions: aryl bromides (0.50 mmol), arylboronic acids (0.75 mmol), L3 (0.75 mmol%), PdCl2 (CH3CN)2 (0.50 mmol%), base (1.50 mmol), toluene (2.0 mL), 80°C, reaction time 10 h.

b Isolated yield.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.