Simultaneous Synthesis of Pyrazolopyridines and Pyrazolopyrimidinones Under Microwave Irradiation

Abstract

The direct reaction of o-aminopyrazocarbonitriles and carbonyl compounds to afford pyrazolopyrimidinones was discovered; hence, a simultaneous synthetic method for pyrazolopyridines and pyrazolopyrimidinones was achieved. Under microwave irradiation, better yields of products than those of conventional method were given.

Keywords:

• Microwave irradiation
• pyrazolopyridines
• pyrazolopyrimidinones
• synthesis

Notes

^a All reactions were carried out at variable power in a Biotage microwave reactor for 10 min using 1 (4 mmol), ZnCl₂ (4.2 mmol), and 2 (3 mL).

^b Isolated yield.