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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 22
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Original Articles

Synthesis of Second- and Third-Generation Asp Oligopeptide Conjugated Dendrimers for Bone-Targeting Drug Delivery

, , &
Pages 4039-4052 | Received 18 Nov 2008, Published online: 16 Oct 2009
 

Abstract

The second- and third-generation multiple dendrimers based on naproxen in core and Asp(4–6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.

Notes

a Naproxen dissolved in anhydrous CH3OH.

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