Mechanically Activated Solid-State Synthesis of Flavones by High-Speed Ball Milling

Abstract

An efficient, mechanically activated solid-state synthesis of flavones from 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones using high-speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time, and neat conditions.

Keywords:

• Ball milling
• flavones
• solid-state synthesis

ACKNOWLEDGMENT

We are grateful to the Natural Science Foundation of China (Nos. 20476098 and 20876147) for financial help.

Notes

^a Reactions were run with 10 mmol of 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione, catalyst and 10 g silica gel.

^b Isolated yield.

^a Reactions were run with 10 mmol of substrate, 1 mmol of KHSO₄, and 10 g silica gel.

^b Isolated yield.

^a Reactions were run with 10 mmol of substrate, 1 mmol of KHSO₄, and 10 g silica gel.

^b Isolated yield.