Abstract
Ionone-based terpenoid-like bischalcones (3a–h and 4a–h) were synthesized from the reaction of α- and/or β-ionones with aldehyde derivatives in excellent yields. The antibacterial activities of synthesized compounds were screened against human pathogenic micro-organisms by employing the disk-diffusion technique.
ACKNOWLEDGMENTS
The authors are indebted to the Department of Chemistry and Biology (Gaziosmapasa University) and the Scientific and Technical Research Council of Turkey [Grant TUBITAK-TBAG (106T103)] for financial support.
Notes
a SCF: Sulbactam (30 µg) + cefoperazona (75 µg) = positive control.
b CH3OH: Methanol = negative control.
Notes. A: Proteus Vulgaris KUEN 1329, B: Candida utilis KUEN 1031, C: Streptococcus homilis, D: E.coli 111, E: Bacillus cereus DSM 4312, F: Pseudomonas aeruginosa ATCC 9027, G: Bacillus subtilis ATCC 6633, H: S. Aureus ATCC 29213, I: Salmonella enteridis ATCC 13076, J: St. Pyogenez ATCC 176, K: Enterococous fecaelis ATCC 29122, L: Candida albicans ATCC 1213.