Microwave-Assisted Simple Synthesis of Substituted 4-Quinolone Derivatives

Abstract

A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.

Keywords:

• Microwave
• 4-quinolone
• synthesis

ACKNOWLEDGMENT

We are grateful to the National Natural Science Foundation of China (NSFC Grant Nos. 30271543 and 30371676) for financial support.

Notes

^a All microwave-catalyzed reactions were performed with a CEM microwave synthesizer, and the power used in the reactions was 280 W.

^b The conventional yields were obtained after thermal cyclization reactions at 250–280°C over 4–10 h.