Simple and Efficient Method for Acetylation of Alcohols, Phenols, Amines, and Thiols Using Anhydrous NiCl₂ Under Solvent-Free Conditions

Abstract

Solvent-free acetylation of alcohols, phenols, amines, and thiols with acetic anhydride (Ac₂O) in the presence of 0.1 mol% (13 mg) anhydrous NiCl₂, an inexpensive and easily available catalyst, is described. Excellent yields, short reaction time, and mild reaction conditions are important features of this method.

Keywords:

• Acetic anhydride
• acetylation
• anhydrous NiCl₂
• solvent-free

ACKNOWLEDGMENT

The authors acknowledge the partial support of this work by Prof. B. P. Bandgar, Vice Chancellor, University of Solapur, India.

Notes

^a Yields refer to pure products, and all products were characterized by comparison of their IR data, ¹H NMR spectrum, and elemental analysis with those of authentic samples.