Simple and Practical Procedure for the Preparation of Benzofurazan-N-oxides in the Presence of Cyclodextrin in Neutral Condition

Abstract

A simple and practical procedure for the aqueous-phase preparation of benzofurazan-N-oxides has been developed in the presence of cyclodextrin at room temperature in neutral condition for the first time. Organic solvent can be precluded for the application of cyclodextrin, which can be recovered and reused in subsequent reactions without loss of activity. The reaction mechanism was studied based on the complexation of cyclodextrin and o-nitroaniline, which was proved by ¹H NMR and IR spectroscopy.

Keywords:

• Benzofurazan-N-oxides
• cyclodextrin
• green chemistry
• neutral condition
• o-nitroaniline