Simple and Efficient One-Pot Synthesis of 2-Substituted Benzoxazole and Benzothiazole

Abstract

2-Substituted benzoxazole and benzothiazole were synthesized from condensation of aldehyde and 2-aminophenol or 2-aminothiophenol via a one-pot process using diethyl bromo phoshonate and tert-butyl hypochlorite.

Keywords:

• 2-Aminophenol
• 2-aminothiophenol
• benzoxazole
• diethyl bromo phoshonate
• tert-butyl hypochlorite

ACKNOWLEDGMENTS

The author thanks Mr. Pravin Patil and Mr. Sachin Narkhede for their valuable suggestions.

Notes

^a Yield by column chromatography.

^b Mp/bp mentioned in (square brackets) are reported in literature.