Facile Synthesis of Coumarinyl Isothiocyanate from Amino Coumarin

Abstract

One-pot conversion of amino coumarin to corresponding coumarinyl isothiocyanate using carbon disulfide, iodine, and pyridine is described. In this reaction, pyridine acts as a solvent as well as a catalyst to give coumarinyl isothiocyanate. Excellent yield, short reaction time, and mild reaction conditions make this method a useful synthetic procedure for one-pot preparation of coumarinyl isothiocyanate.

Keywords:

• Amino coumarin
• coumarinyl isothiocyanate
• iodine
• pyridine
• pyridinium hydroiodide

ACKNOWLEDGMENT

Authors are thankful to the director, Institute of Science, for providing the necessary facility.