Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors

Liutang Wang West China School of Pharmacy, Sichuan University, Chengdu, China; Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Bin Zhang Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Jianxin Ji Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Bogang Li Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Jufang Yan Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Weiyu Zhang Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

Yong Wu West China School of Pharmacy, Sichuan University, Chengdu, ChinaCorrespondence[email protected]

Xuechao Wang West China School of Pharmacy, Sichuan University, Chengdu, China; Department of Research and Development, Di'ao Co. Ltd, Chengdu, ChinaCorrespondence[email protected]

Hui Hou Department of Research and Development, Di'ao Co. Ltd, Chengdu, China

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Abstract

A series of new 2-cyanopyrrolidine derivatives with constrained imidazolidin ring were synthesized, Their structures were confirmed by ¹H NMR spectroscopy and/or mass spectrometry, and their activities were evaluated in vitro. They were proven to possess submicromolar inhibitory activities against dipeptidyl peptidase IV.

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Notes

Note. Values are IC₅₀ (μM) expressed as the mean of three independent determinations.

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Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors

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Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors

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