Abstract
2-Amino[1,3]benzothiazoles can be efficiently used as substrates for the Groebke–Blackburn (GB) reaction using equimolar trimethylsilyl chloride (TMSCl) as a promoter. This finding extends the utility of TMSCl in isocyanide-based multicomponent reactions (MCRs) and expands the scope of reactive 2-aminoazole participants for the GBMCR.
Notes
a The number in parentheses indicates the yield after crystallization.