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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2009 - Issue 1
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Original Articles

Fast, Solvent-Free, Microwave-Promoted Friedländer Annulation with a Reusable Solid Catalyst

, , , , &
Pages 120-128 | Received 20 Dec 2008, Published online: 09 Dec 2009
 

Abstract

A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedländer cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h).

ACKNOWLEDGMENTS

Support of this research by the University of Turin is gratefully acknowledged. Z. R. thanks the World Wide Style (WWS) Project. Part of this work comes from the degree thesis of Christian Speranza.

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