Unexpected and Green Synthesis of Azapodophyllotoxin Derivatives via Microwave-Assisted Multicomponent Reactions in Ammonia Water

Abstract

An unexpected and green synthesis of azapodophyllotoxin derivatives was realized via microwave-assisted multicomponent reactions of dimedone, tetronic acid, and aromatic aldehydes in ammonia water. This protocol has the advantages of environmental friendliness, short reaction time, good yields, low cost, and easy operation.

Keywords:

• Azapodophyllotoxin
• green synthesis
• microwave irradiation
• water

ACKNOWLEDGMENTS

We thank the National Natural Science Foundation of China (Nos. 20672090 and 20810102050), the Key Item of Natural Science Foundation of Xuzhou Normal University (No. 07XLA04), the Preliminary Item of Xuzhou Normal University on National Natural Science Foundation of China (No. 08XLY04), the Natural Science Foundation (09KJB150011) and Qing Lan Project (08QLT001) of Jiangsu Education Committee, and the Science and Technology Foundation of Xuzhou (No. XM08C027) for financial support.