Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2009 - Issue 2
1,024
Views
53
CrossRef citations to date
0
Altmetric
Original Articles

Three-Component Reaction to Form 1,4-Dihydropyrano[2,3-c]pyrazol-5-yl Cyanides

&
Pages 257-265 | Received 26 Jan 2009, Published online: 29 Dec 2009
 

Abstract

The three-component reactions of 3-alkyl-1-phenyl-2-pyrazolin-5-ones, aryl aldehydes, and malononitrile in the presence of base catalysts such as sodium acetate, triethylamine, and magnesium oxide (MgO) are investigated. Magnesium oxide (MgO) effectively catalyzes these reactions to form 1,4-dihydropyrano[2,3-c]pyrazol-5-yl cyanide derivatives. The salient features of this method include high conversions, short reaction times, cleaner reaction profiles, and the use of inexpensive and readily available catalyst.

ACKNOWLEDGMENTS

The authors express appreciation to the Shahid Bahonar University of Kerman Faculty Research Committee for its support of this investigation.

Notes

a Commercial MgO.

b High-surface-area MgO.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.