Efficient Synthesis of 6-Amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile Under Solvent-Free Conditions

Liangce Rong College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, ChinaCorrespondence[email protected]

Lijiu Gao College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China

Hongxia Han College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China

Hong Jiang Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, China

Yisi Dai College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China

Shujiang Tu College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, China

Abstract

A series of 6-amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitriles were prepared in good yields under solvent-free conditions by multicomponent reactions of aromatic aldehyde, malononitrile, and 1-methylpiperidin-4-one in the presence of sodium hydroxide (NaOH). The structures of the products were characterized by infrared, ¹H NMR spectra, elemental analysis, and high-resolution mass spectrometery (HRMS).

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ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Pei Yu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.

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Efficient Synthesis of 6-Amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile Under Solvent-Free Conditions

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Efficient Synthesis of 6-Amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile Under Solvent-Free Conditions

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