Preparation of Isoquinolin-(2(1H)-yl)but-2-enedioate Derivatives

Abstract

One-pot, three-component reactions of isoquinoline, dimethyl/diethyl acetylenedicarboxylate, and indole, carbazole, pyrazole, or imidazole gave dimethyl/diethyl 2-(1-(1H-indol-1-yl)isoquinolin-2(1H)-yl)but-2-enedioate, dimethyl/diethyl 2-(1-(9H-carbazol-9-yl)isoquinolin-2(1H)-yl)but-2-enedioate, dimethyl 2-(1-(1H-pyrazol-1-yl)isoquinolin-2(1H)-yl)but-2-enedioate, or dimethyl 2-(1-(1H-imidazol-1-yl)isoquinolin-2(1H)-yl)but-2-enedioate respectively in good to excellent yields.

Keywords:

• Carbazole
• dialkyl acetylenedicarboxylate
• indole
• isoquinolin-2(1H)-yl)but-2-enedioate
• isoquinoline

ACKNOWLEDGMENTS

We are thankful to the Islamic Azad University of Neyriz and Islamic Azad University of Yazd Research Council for the partial support of this research.

Notes

^a Isolated yield.