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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 3
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Original Articles

Chemoselective Synthesis of 1,1-Diacetates from Aldehydes Using Anhydrous Cobalt(II) Bromide Under Solvent-Free Conditions

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Pages 442-449 | Received 19 Jan 2009, Published online: 06 Jan 2010
 

Abstract

A mild and efficient method has been developed for the chemoselective preparation of 1,1-diacetates (acylals) from aldehydes catalyzed in the presence of a catalytic amount (0.1 mmol) of anhydrous cobalt(II) bromide under solvent-free conditions. The remarkable selectivity under mild and neutral conditions, excellent yields, short reaction time, and easily available and inexpensive catalyst are important features of this method.

ACKNOWLEDGMENT

We thank the Faculty of Chemistry, University of Mumbai, India, for supporting this work.

Notes

a Isolated yield.

b The solvent-free reaction is more effective.

a Isolated yield of the corresponding sulfonylated product.

a Yields refer to pure products, and all products were characterized by comparison of their infrared (IR) and 1H NMR spectra.

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