Synthesis and Antimicrobial Activity of Pyrazolyl 1,3,4-Oxadiazoles

Abstract

The pyrazolyl oxadiazoles are synthesized from arylsulfonylacetic acid methyl ester and benzylsulfonylacetic acid methyl ester. Preliminary antimicrobial screening of the compounds showed that bis heterocycles with a chloro-substituted benzyl moiety exhibited high activity.

Keywords:

• Antimicrobial activity
• 1,3-dipolar cycloaddition
• 1,3,4-oxadiazoles
• pyrazolines

ACKNOWLEDGMENT

The authors are thankful to the Department of Science and Technology, New Delhi, India, for the financial assistance as a major research project.