Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 4
222
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Novel System for the Synthesis of Nitriles from Aldehydes Using Aqueous Ammonia and [Bis(Trifluoroacetoxy)iodo]benzene

, &
Pages 494-497 | Received 31 Jan 2009, Published online: 03 Feb 2010
 

Abstract

A simple and mild method for the conversion of varieties of aldehydes to the corresponding nitriles using aqueous ammonia and trivalent hypervalent iodine reagent, [bis(trifluoroacetoxy)iodo]benzene, at room temperature is discussed. Advantages of this system are short reaction time, easy workup, and moderate to good yields.

ACKNOWLEDGMENT

We gratefully acknowledge the University Grants Commission, India, for financial support under the scheme of a UGC major research project.

Notes

a Reaction conditions: substrate (4.5 mmol), [bis(trifluoroacetoxy)iodo]benzene (1.2 equiv, 5.4 mmol), aqueous ammonia (15 mL), rt.

b Starting compounds were prepared by standard literature procedures.

c Isolated yields after column chromatography. Structures were confirmed by comparison of IR and 1H NMR with those of authentic materials.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.