Green Synthesis of Some New (Substituted Fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines

Abstract

A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–j) with α-bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.

Keywords:

• Fluorobenzoylimino-1,3-thiazolines
• green synthesis

ACKNOWLEDGMENT

The authors gratefully acknowledge the research grant from Quaid-I-Azam University, Islamabad.

Notes

Recrystallization solvent: ethanol/methanol.