Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 4
93
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Green Synthesis of Some New (Substituted Fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines

&
Pages 564-569 | Received 26 Feb 2009, Published online: 03 Feb 2010
 

Abstract

A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–j) with α-bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.

ACKNOWLEDGMENT

The authors gratefully acknowledge the research grant from Quaid-I-Azam University, Islamabad.

Notes

Recrystallization solvent: ethanol/methanol.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.