Lithium Bromide as a Mild, Efficient, and Recyclable Catalyst for the One-Pot Synthesis of Tetrahydro-4H-Chromene Derivatives in Aqueous Media

Abstract

A simple, efficient, one-pot method has been developed for the synthesis of tetrahydro-4H-chromene derivatives by concurrent reaction of aryl aldehydes, active methylene compounds, and 1,3-cyclohexanedins using a catalytic amount of lithium bromide in aqueous media. The present approach offers several advantages such as shorter reaction times, good yields, low cost, recycling of the catalyst, and simple workup.

Keywords:

• Aqueous media
• 4H-chromene
• lithium bromide
• multicomponent reaction
• one-pot synthesis

ACKNOWLEDGMENTS

We are grateful for financial support from the National Natural Science Foundation of China (20872025), Natural Science Foundation of Hebei Province (B2008000149), Natural Science Foundation of Hebei Education Department (2006318), and Research Foundation for the Doctoral Program of Hebei Normal University (L20061314).

Notes

^a Isolated yield.

^a Isolated yield.