Stereoselective Synthesis of Substituted 2-(Z-Styrylsulfonyl)-1H-imidazoles and Benzothiazole

Abstract

A novel method has been reported involving the synthesis of z-styryl sulfides by the reaction of phenylacetylene with 2-mercpto benzimidazoles and benzthiazole using NaOH as a base in absolute ethanol. On further oxidation with H₂O₂, these resulted in the formation of the desired styryl sulfones in good yields with retention of stereochemistry.

Keywords:

• 2-Mercaptoimidazoles
• phenylacetylene
• styryl sulfides
• sulfones

ACKNOWLEDGMENT

This work was supported by grants from the Council of Scientific Industrial Research (CSIR), New Delhi, for Project No. 01 (2062) 06/EMR-II.