N-Nitrosation of Secondary Amines Using p-TSA-NaNO₂ as a Novel Nitrosating Agent Under Mild Conditions

Abstract

A combination of p-toluenesulfonic acid (p-TSA) and sodium nitrite was used as a novel effective nitrosating agent for the N-nitrosation of secondary amines to their corresponding nitroso derivatives under mild and heterogeneous conditions in moderate to excellent yields.

Keywords:

• N-nitrosation
• nitroso amines
• secondary amines
• p-toluenesulfonic acid

ACKNOWLEDGMENT

This work was carried out under Indo-Hungarian Inter-Governmental joint project (P90807) and is gratefully acknowledged.

Notes

^a All products are known, and their spectral and physical data are in accordance with authentic samples.

^b Isolated yields.