Green, Microwave-Assisted Approach to the Synthesis of Arylidene-Substituted Spiro[4,5]decan-8-one Derivatives in Water

Abstract

A green approach to the synthesis of arylidene-substituted spiro[4,5]decan-8-one derivatives was successfully realized via the mild, base-catalyzed reaction of aromatic aldehydes with 1,4-dioxa-spiro[4.5]decan-8-one in water under microwave irradiation. This protocol has the prominent advantages of environmental friendliness, short reaction time, excellent yields, low cost, easy operation, and broad scope of applicability.

Keywords:

• Green synthesis
• microwave irradiation
• water

ACKNOWLEDGMENTS

We thank the National Natural Science Foundation of China (Nos. 20672090 and 200810102050) and the Key Item program of the Natural Science Foundation of Xuzhou Normal University (No. 07XLA04) for financial support.