Sulfamic Acid–Catalyzed, Three-Component, One-Pot Synthesis of [1,2,4]Triazolo/Benzimidazolo Quinazolinone Derivatives

Abstract

An efficient and convenient approach is reported for three-component, one-pot synthesis of the [1,2,4]triazolo/benzimidazolo quinazolinones by condensation of 2-amino benzimidazole or 3-amino-1,2,4-triazole as amine sources with dimedone and different aldehydes in the presence of sulfamic acid as a reusable, green catalyst in acetonitrile and under heating conditions.

Keywords:

• 2-Amino benzimidazole
• 3-amino-1,2,4-triazole
• sulfamic acid
• triazolo/benzimidazolo quinazolinones

ACKNOWLEDGMENT

The authors are thankful to the Azzahra Research Council for partial financial support.

Notes

^a Isolated yield.

^a All the products were fully characterized by the usual spectroscopic techniques.

^b Isolated yield.

^a Isolated yield.