Clean and Convenient One-Pot Synthesis of 4-Hydroxycoumarin and 4-Hydroxy-2-quinolinone Derivatives

Abstract

A simple, efficient, and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with phenol, substituted phenols, aniline, or substituted anilines with Eaton's reagent (phosphoric anhydride + methylsulfonic acid) as cyclization reagent. 4-Hydroxycoumarins and 4-hydroxy-2-quinolinones were synthesized in moderate yields by carrying out the reaction in solvent-free, convenient, and clean one-pot preparation.

Keywords:

• Eaton's reagent
• 4-hydroxycoumarin
• 4-hydroxy-2-quinolinone
• one-pot

ACKNOWLEDGMENT

The financial support provided by Science Foundation of Liaoning Province of China (No. 202, 142, 037) is sincerely acknowledged.