Synthesis and Bioactivities of Clopyralid Hydrazide-Hydrazones

Abstract

A series of clopyralid hydrazide-hydrazone derivatives (4a–p) have been synthesized. Their structures were confirmed by elemental analysis, infrared, and ¹H NMR spectra. The bioactivities of compounds 4a–p were tested with barnyard grass, rape, and S. aureus, but the results showed that they could not be considered the promising herbicidal or antibacterial agents.

Keywords:

• Bioactivities
• clopyralid
• hydrazide-hydrazone
• synthesis

ACKNOWLEDGMENTS

This work was supported by the Top Key Discipline of Applied Chemistry of Zhejiang Province and the State Key Laboratory Breeding Base of Green Chemistry–Synthesis Technology.

Notes

^a P:E, petrolum ether/ethyl acetate.

^b Decomposition temperature.

^a vs, very strong; s, strong; m, medium.

^b υ (Py-2,3,6) = 2,3,6-trisubstituted pyridine.

^a py = py, bz = benzene, cy = cyclopentylidene.