Effective Synthesis of Polysubstituted Pyrroles from (E)-Dimethyl 2-(Bromomethyl)-3-(diethoxyphosphoryl) Fumarate

Abstract

Methyl 1-alkyl-4-(diethoxyphosphoryl)-5-oxo-2,5-dihydro-1H-pyrroles-3-carboxylate 4 was synthesized from the reaction of dimethyl 2-(bromomethyl)-3-(diethoxyphosphoryl) fumarate 3- E and primary amines in good yields.

Keywords:

• Cyclization reaction
• dimethyl 2-(bromomethyl)-3-(diethoxyphosphoryl) fumarate
• polysubstituted methyl 5-oxo-2,5-dihydro-1H-pyrroles-3-carboxylate primary amines