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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 6
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Original Articles

Parallel Synthesis of Novel 3-Substituted 1-Ethyl-6-methylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione Analogs

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Pages 821-832 | Received 25 Mar 2009, Published online: 22 Feb 2010
 

Abstract

A library of novel 1H-pyrimido[4,5-c]pyridazine-5,7-dione analogs was prepared in a parallel fashion via the cyclization of 6-(1-ethylhydrazinyl)-3-methylpyrimidine-2,4(1H,3H)-dione (4) with α-bromoketones and was then isolated by a two-step purification method with >90% purity. Both the library synthesis and purification method proved suitable for analogs with a high diversity of substitution at the 3-position including various alkyl, aryl, and heteroaryl groups.

ACKNOWLEDGMENT

We thank Dr. Linyi Wei for his helpful suggestion on intermediate synthesis.

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